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Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.

Original publication

DOI

10.1128/jcm.03142-15

Type

Journal article

Journal

Journal of clinical microbiology

Publication Date

05/2016

Volume

54

Pages

1388 - 1390

Addresses

Modernising Medical Microbiology Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom anna.sheppard@ndm.ox.ac.uk aseale@nhs.net.

Keywords

Modernising Medical Microbiology Informatics Group, Humans, Streptococcus agalactiae, Bacterial Capsules, Serotyping, Sequence Analysis, DNA, Genome, Bacterial, Molecular Typing