Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data.
Sheppard AE., Vaughan A., Jones N., Turner P., Turner C., Efstratiou A., Patel D., Walker AS., Berkley JA., Crook DW., Seale AC.
Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.