Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data.
Sheppard AE., Vaughan A., Jones N., Turner P., Turner C., Efstratiou A., Patel D., Modernising Medical Microbiology Informatics Group None., Walker AS., Berkley JA., Crook DW., Seale AC.
Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.