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Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).We observed no significant association between genetic variants and prostate cancer survival.Common genetic variants with large impact on prostate cancer survival were not observed in this study.Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Original publication

DOI

10.1158/1055-9965.EPI-15-0543

Type

Journal article

Journal

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Publication Date

11/2015

Volume

24

Pages

1796 - 1800

Addresses

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. Academic Primary Healthcare Center, Stockholm County Council, Karolinska Institute, Stockholm, Sweden. robert.szulkin@ki.se.

Keywords

PRACTICAL consortium, Australian Prostate Cancer BioResource, BPC3 consortium, Humans, Prostatic Neoplasms, Survival Analysis, Polymorphism, Single Nucleotide, Male, Genome-Wide Association Study