The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates p(heterogeneity) = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.

Original publication

DOI

10.1093/aje/kwm161

Type

Journal article

Journal

American journal of epidemiology

Publication Date

10/2007

Volume

166

Pages

912 - 923

Addresses

Nutrition and Hormones Unit, International Agency for Research on Cancer, Lyon, France. annec@health.usyd.edu.au

Keywords

Humans, Endometrial Neoplasms, Starch, Dietary Carbohydrates, Hormone Replacement Therapy, Diet Surveys, Nutrition Assessment, Incidence, Multivariate Analysis, Confidence Intervals, Proportional Hazards Models, Risk Assessment, Risk Factors, Cohort Studies, Follow-Up Studies, Prospective Studies, Feeding Behavior, Glycemic Index, European Union, Dietary Fiber, Middle Aged, Europe, Female, Surveys and Questionnaires