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This paper reviews the developments in high-throughput and nanolitre-scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception in October 2002. By surveying the uptake, use and experience of new technologies by SPINE partners across Europe, a picture emerges of highly successful adoption of novel working methods revolutionizing this area of structural biology. Finally, a forward view is taken of how crystallization methodologies may develop in the future.

Original publication




Journal article


Acta crystallographica. Section D, Biological crystallography

Publication Date





1137 - 1149


Division of Structural Biology and Oxford Protein Production Facility (OPPF), Wellcome Trust Centre for Human Genetics, Oxford, England.


Plastics, Proteins, Crystallography, Proteomics, Robotics, Nanotechnology, Quality Control, Image Processing, Computer-Assisted