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This paper reviews the developments in high-throughput and nanolitre-scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception in October 2002. By surveying the uptake, use and experience of new technologies by SPINE partners across Europe, a picture emerges of highly successful adoption of novel working methods revolutionizing this area of structural biology. Finally, a forward view is taken of how crystallization methodologies may develop in the future.

Original publication

DOI

10.1107/s090744490602943x

Type

Journal article

Journal

Acta crystallographica. Section D, Biological crystallography

Publication Date

10/2006

Volume

62

Pages

1137 - 1149

Addresses

Division of Structural Biology and Oxford Protein Production Facility (OPPF), Wellcome Trust Centre for Human Genetics, Oxford, England.

Keywords

Plastics, Proteins, Crystallography, Proteomics, Robotics, Nanotechnology, Quality Control, Image Processing, Computer-Assisted