Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study.
Sousa-Pinto B., Louis G., Rodrigues J., Giuliano AFM., Baiardini I., Braido F., Czarlewski W., Bedbrook A., Haahtela T., Valiulis A., Brussino L., Cecchi L., Cruz AA., Gemicioglu B., Fokkens WJ., Ivancevich JC., Klimek L., Kraxner H., Kuna P., Kupczyk M., Kvedariene V., Larenas-Linnemann D., Louis R., Nadif R., Niedoszytko M., Okamoto Y., Ollert M., Papadopoulos NG., Patella V., Pawankar R., Pham-Thi N., Pfaar O., Regateiro FS., Roche N., Rouadi PW., Samolinski B., Sastre J., Savouré M., Scichilone N., Sheikh A., Taborda-Barata L., Toppila-Salmi S., Yorgancioglu A., Zidarn M., Anto JM., Zuberbier T., Canonica GW., Ventura MT., Fonseca JA., Pétré B., Bousquet J.
BackgroundEQ-5D-5L (EuroQOL, 5 Domains, 5 Levels) is a widely used health-related quality-of-life instrument, comprising 5 domains. However, it is not known how each domain is impacted by rhinitis or asthma control.ObjectiveTo assess the association between rhinitis or asthma control and the different EQ-5D-5L domains using data from the MASK-air mHealth app.MethodsIn this cross-sectional study, we assessed data from all MASK-air users (2015-2021; 24 countries). For the levels of each EQ-5D-5L domain, we assessed rhinitis and asthma visual analog scales (VASs) and the combined symptom-medication score (CSMS). We built ordinal multivariable models assessing the adjusted association between VAS/CSMS values and the levels of each EQ-5D-5L domain. Finally, we compared EQ-5D-5L data from users with rhinitis and self-reported asthma with data from users with rhinitis alone.ResultsWe assessed 5354 days from 3092 users. We observed an association between worse control of rhinitis or asthma (higher VASs and CSMS) and worse EQ-5D-5L levels. In multivariable models, all VASs and the CSMS were associated with higher levels of pain/discomfort and daily activities. For anxiety/depression, the association was mostly observed for rhinitis-related tools (VAS nose, VAS global, and CSMS), although the presence of self-reported asthma was also associated with worse anxiety/depression. Worse mobility ("walking around") was particularly associated with VAS asthma and with the presence of asthma.ConclusionsA worse rhinitis control and a worse asthma control are associated with higher EQ-5D-5L levels, particularly regarding pain/discomfort and activity impairment. Worse rhinitis control is associated with worse anxiety/depression, and poor asthma control with worse mobility.