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Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.

Original publication

DOI

10.1093/ofid/ofaa158

Type

Journal article

Journal

Open forum infectious diseases

Publication Date

07/05/2020

Volume

7

Addresses

Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, The University of Sydney, Sydney, Australia.