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The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Original publication

DOI

10.1038/s41588-019-0378-y

Type

Journal article

Journal

Nature genetics

Publication Date

04/2019

Volume

51

Pages

636 - 648

Addresses

Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. amy.bentley@nih.gov.

Keywords

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Lifelines Cohort, Humans, Lipids, Smoking, Life Style, Genotype, Linkage Disequilibrium, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study, Young Adult