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The application of regular herd testing to identify and remove infected animals has proved to be a highly successful method of controlling bovine tuberculosis (TB) in many parts of the world. However, in some countries, notably the United Kingdom, Ireland and New Zealand, the disease has continued to pose a significant problem, despite intensive herd testing. Persistence of disease in these countries is associated with the presence of wildlife reservoirs of infection. Attempts to control bovine TB by culling of wildlife have been, at best, only partially successful and have proved difficult to sustain. This has led to considering of vaccination either of wildlife or cattle as a potential control measure. However, there are a number of obstacles that need to be overcome before vaccination can be considered a practical option. Vaccine efficacy, methods used for vaccine delivery in wildlife, potential interference of vaccination with diagnostic tests for cattle and appropriate design of field trials are among the issues that need to be addressed.

Type

Journal article

Journal

Developments in biologicals

Publication Date

01/2004

Volume

119

Pages

351 - 359

Addresses

Centre for Tropical Veterinary Medicine, Royal (Dick) School of Veterinary Medicine, University of Edinburgh, Roslin, Midlothian, UK. ivan.morrison@ed.ac.uk

Keywords

Animals, Animals, Wild, Cattle, Mustelidae, Mycobacterium bovis, Tuberculosis, Tuberculosis, Bovine, Tuberculosis Vaccines, Vaccination, Euthanasia, Animal, Disease Reservoirs