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We describe software which calculates a set of linkage disequilibrium statistics, including multiallelic D' corrected by the bootstrap and permutation. The software also provides a tool for maximum likelihood and least squares estimation and testing of a set of hierarchical hypotheses formulated within the framework of the Malecot model of the decay of linkage disequilibrium with distance. Additionally, the bootstrap approach is used for estimation of the model parameter's confidence intervals and for hypothesis testing. The programs are available from http://www.geneticepi.com/Research/software/software.html

Original publication

DOI

10.1046/j.1469-1809.2003.00041.x

Type

Journal article

Journal

Annals of human genetics

Publication Date

07/2003

Volume

67

Pages

372 - 375

Addresses

Genetic Epidemiology Unit, Department of Epidemiology & Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands. i.aoultchenko@erasmusmc.nl

Keywords

Likelihood Functions, Linkage Disequilibrium, Algorithms, Models, Genetic