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Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

Original publication

DOI

10.1002/ana.10106

Type

Journal article

Journal

Annals of neurology

Publication Date

02/2002

Volume

51

Pages

253 - 256

Addresses

Department of Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. bonifati@kgen.fgg.eur.nl

Keywords

Chromosomes, Human, Pair 1, Humans, Parkinsonian Disorders, Ligases, Ubiquitin-Protein Ligases, Pedigree, Age of Onset, Lod Score, Adult, Middle Aged, Family Health, Female, Male