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We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Original publication

DOI

10.1016/s0304-3940(98)00931-8

Type

Journal article

Journal

Neuroscience letters

Publication Date

02/1999

Volume

260

Pages

193 - 195

Addresses

Mayo Clinic Jacksonville, FL 32224, USA.

Keywords

Chromosomes, Human, Pair 17, Humans, Parkinson Disease, Dementia, Apolipoproteins E, tau Proteins, Age of Onset, Genotype, Mutation, Missense, Aged, Middle Aged