Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.

Original publication

DOI

10.1212/wnl.59.5.746

Type

Journal article

Journal

Neurology

Publication Date

09/2002

Volume

59

Pages

746 - 748

Addresses

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.

Keywords

Amygdala, Hippocampus, Humans, Brain Diseases, Atrophy, Apolipoproteins E, Magnetic Resonance Imaging, Cognition, Genotype, Heterozygote, Aged, Female, Male, Apolipoprotein E2, Apolipoprotein E4