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The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.

Original publication

DOI

10.1038/ng1770

Type

Journal article

Journal

Nature genetics

Publication Date

05/2006

Volume

38

Pages

556 - 560

Addresses

Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA.

Keywords

Chromosomes, Human, Pair 22, Humans, Genetics, Population, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome, Human