Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVES:To assess the genetic risk of open-angle glaucoma (OAG) in individuals by calculating a family score (FS), which summarizes the information of all relatives including their disease status, age, sex, and degree of kinship and to examine the genetic contribution to OAG with and without an increased intraocular pressure. METHODS:Case and control probands, derived from the Rotterdam Study, underwent the same ophthalmologic examination as their relatives. The FS of each proband was the sum of the differences between observed and expected values of OAG for all relatives. The FSs were compared between case and control probands using logistic regression analysis, adjusted for intraocular pressure. RESULTS:Of 37 case probands, 44 (half-) siblings and 86 children were available, and of 83 control probands there were 97 (half-) siblings and 155 children. Family scores ranged from -0.44 to 7.08 in case probands and from -0.98 to 2.46 in control probands. One unit increase in FS was significantly associated with a higher risk of OAG (odds ratio, 1.59; 95% confidence interval, 1.14-2.23). Adjustments for intraocular pressure did not change the odds ratio. CONCLUSIONS:These data show that the FS strongly predicts OAG, independent of the intraocular pressure. Therefore, the FS is useful to identify individuals with a high genetic risk.

Original publication

DOI

10.1001/archopht.120.12.1726

Type

Journal article

Journal

Archives of ophthalmology (Chicago, Ill. : 1960)

Publication Date

12/2002

Volume

120

Pages

1726 - 1731

Addresses

The Netherlands Ophthalmic Research Institute, KNAW, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands.

Keywords

Humans, Glaucoma, Open-Angle, Prevalence, Logistic Models, Risk Factors, Nuclear Family, Intraocular Pressure, Models, Genetic, Aged, Aged, 80 and over, Middle Aged, Family Health, Netherlands, Female, Male