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Low birthweight is associated with later risk of type 2 diabetes and related disorders. We aimed to show that a polymorphism in the gene for insulin-like growth factor-I, which has proved to raise risk of type 2 diabetes and myocardial infarction, is associated with low birthweight. We recorded birthweight and obtained DNA for 463 adults. Individuals who did not have the wild-type allele of the polymorphism had a 215 g lower birthweight than those homozygous for this allele (95% CI -411 to -10). Our data lend support to the hypothesis that genetic variation affecting fetal growth could account for the association between low birthweight and susceptibility to diabetes and cardiovascular disease in later life.

Original publication

DOI

10.1016/s0140-6736(02)08067-4

Type

Journal article

Journal

Lancet (London, England)

Publication Date

03/2002

Volume

359

Pages

1036 - 1037

Addresses

Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Centre Rotterdam, The Netherlands.

Keywords

Humans, Myocardial Infarction, Diabetes Mellitus, Type 2, Insulin-Like Growth Factor I, Genotype, Adult, Infant, Newborn, Infant, Low Birth Weight, Genetic Variation