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We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.

Original publication

DOI

10.1016/j.amjcard.2004.04.044

Type

Journal article

Journal

The American journal of cardiology

Publication Date

08/2004

Volume

94

Pages

384 - 386

Addresses

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.

Keywords

Humans, Genetic Predisposition to Disease, Insulin-Like Growth Factor I, Prognosis, Incidence, Confidence Intervals, Proportional Hazards Models, Risk Assessment, Survival Analysis, Cohort Studies, Prospective Studies, Age Distribution, Sex Distribution, Polymorphism, Genetic, Alleles, Female, Male, Heart Failure, Promoter Regions, Genetic