Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study).
Bleumink GS., Rietveld I., Janssen JAMJL., van Rossum EFC., Deckers JW., Hofman A., Witteman JCM., van Duijn CM., Stricker BHC.
We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.