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Age of onset was examined for 139 members of 30 families affected by early-onset AD. Most (77%) of the variance of age of onset derived from differences between rather than within families. The constancy of age of onset within families was also observed in an analysis restricted to families derived from a population-based epidemiological study with complete ascertainment of early-onset AD. Furthermore, we observed clustering of age of onset within those families that support linkage to the predisposing locus on chromosome 21. Our data are compatible with the view that allelic heterogeneity at the AD locus may account for the similarity in age of onset within families. This finding may be of value for scientific studies of AD as well as for genetic counselling.

Original publication

DOI

10.1192/bjp.158.4.471

Type

Journal article

Journal

The British journal of psychiatry : the journal of mental science

Publication Date

04/1991

Volume

158

Pages

471 - 474

Addresses

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.

Keywords

Chromosomes, Human, Pair 21, Humans, Alzheimer Disease, Chromosome Disorders, Chromosome Aberrations, Genetic Markers, Risk Factors, Genes, Dominant, Alleles, Models, Genetic, Aged, Middle Aged, Genetic Linkage, Genetic Carrier Screening