Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Studies of risk factors for Alzheimer's disease have been hampered by low statistical power. The data from 11 case-control studies were pooled and re-analysed to evaluate the evidence for the association of Alzheimer's disease with family history of dementia and related disorders, parental age, medical history, and environmental factors. This paper gives a brief description of the participating studies and discusses the strategy that has been followed in the collaborative analysis.

Original publication




Journal article


International journal of epidemiology

Publication Date



20 Suppl 2


S4 - 12


Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.


Humans, Alzheimer Disease, Risk Factors, Case-Control Studies, Adult, Aged, Middle Aged, United States, Australia, Europe, Female, Male, Meta-Analysis as Topic