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BACKGROUND: Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI). We examined the SNPs in relation to the risk of CHD and MI in a large population based study of elderly population. METHODS: The Rotterdam Study is a population-based, prospective cohort study among 7983 participants aged 55 years and older. Associations of the polymorphisms with CHD and MI were assessed by use of Cox proportional hazards analyses. RESULTS: In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274. The corresponding HRs were 1.03 (0.90, 1.18) and 0.93 (0.81, 1.06) for the G allele of rs10757278. The association of the SNPs with CHD and MI was not significant in any of the subgroups of CHD risk factors. CONCLUSION: we were not able to show an association of the studied SNPs with risks of CHD and MI. This may be due to differences in genes involved in the occurrence of CHD in young and older people.

Original publication

DOI

10.1186/1741-7015-6-30

Type

Journal article

Journal

BMC medicine

Publication Date

01/2008

Volume

6

Addresses

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. a.dehghan@erasmusmc.nl

Keywords

Humans, Coronary Disease, Myocardial Infarction, Genetic Predisposition to Disease, Incidence, Proportional Hazards Models, Cohort Studies, Prospective Studies, Gene Frequency, Genotype, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Female, Male, Cyclin-Dependent Kinase 2