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We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

Original publication

DOI

10.1038/ng.416

Type

Journal article

Journal

Nature genetics

Publication Date

08/2009

Volume

41

Pages

879 - 881

Addresses

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. emelia@bu.edu

Keywords

Chromosomes, Human, Pair 16, Humans, Atrial Fibrillation, Genetic Predisposition to Disease, Homeodomain Proteins, Reproducibility of Results, Mutation, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Meta-Analysis as Topic, Genome-Wide Association Study