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Despite extensive research of genetic determinants of human adult height, the genes identified up until now allow to predict only a small proportion of the trait's variance. To identify new genes we analyzed 2,486 genotyped and phenotyped individuals in a large pedigree including 23,612 members in 18 generations. The pedigree was derived from a young genetically isolated Dutch population, where genetic heterogeneity is expected to be low and linkage disequilibrium has been shown to be increased. Complex segregation analysis confirmed high heritability of adult height, and suggested mixed model of height inheritance in this population. The estimates of the model parameters obtained from complex segregation analysis were used in parametric linkage analysis, which highlighted three genome-wide significant and additionally at least four suggestive loci involved in height. Significant peaks were located at the chromosomal regions 1p32 (LOD score = 3.35), 2p16 (LOD score = 3.29) and 16q24 (LOD score = 3.94). For the latter region, a strong association signal (FDR q < 0.05) was obtained for 19 SNPs, 17 of them were located in the CDH13 (cadherin 13) gene of which one (rs1035569) explained 1.5% of the total height variance.

Original publication

DOI

10.1007/s00439-009-0686-x

Type

Journal article

Journal

Human genetics

Publication Date

09/2009

Volume

126

Pages

457 - 471

Addresses

Institute of Cytology and Genetics SD RAS, Russian Academy of Science, Lavrentyev ave. 10, 630090, Novosibirsk, Russia. aks@bionet.nsc.ru

Keywords

Humans, Body Height, Reproducibility of Results, Pedigree, DNA Mutational Analysis, Genetics, Population, Genotype, Lod Score, Phenotype, Models, Genetic, Software, Adult, Netherlands, Female, Male, Genetic Linkage