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Subjects with Down syndrome (DS) have abnormalities in virtually all aspects of the immune system and almost all will be affected with Alzheimer's disease (AD). It is thought that nitric oxide (NO) is involved in the pathophysiology of AD. In the present study, including a total of 401 elderly DS subjects, the spectrum of plasma amino acids and neopterin was investigated and related to development of AD. Concentrations of nearly all amino acids in DS subjects differed significantly from those of healthy controls. Neopterin was increased in DS subjects, especially in dementia. The production of NO as reflected by an increased citrulline/arginine ratio (Cit/Arg ratio) was enhanced during development of clinical dementia. Neopterin concentrations correlated to the Cit/Arg ratio only in the group of prevalent demented subjects (rho = 0.48, P = 0.006). The results of this study are suggestive for an increase in oxidative processes in DS subjects with AD.

Original publication

DOI

10.1007/s00726-009-0300-5

Type

Journal article

Journal

Amino acids

Publication Date

03/2010

Volume

38

Pages

923 - 928

Addresses

Centre for the Intellectually Disabled, Dichterbij, Gennep, The Netherlands. a.coppus@erasmusmc.nl

Keywords

Humans, Dementia, Alzheimer Disease, Epilepsy, Down Syndrome, Nitric Oxide, Neopterin, Amino Acids, Arginine, Amino Acids, Branched-Chain, Amino Acids, Aromatic, Citrulline, Severity of Illness Index, Cohort Studies, Depression, Oxidative Stress, Middle Aged, Female, Male, Intellectual Disability