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While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)-levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.

Original publication

DOI

10.1007/s10654-010-9476-y

Type

Journal article

Journal

European journal of epidemiology

Publication Date

08/2010

Volume

25

Pages

561 - 568

Addresses

Genetic Epidemiology Unit Ee2173, Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. m.schuur@erasmusmc.nl

Keywords

Humans, Insulin Resistance, Metabolic Syndrome X, C-Reactive Protein, Linear Models, Cohort Studies, Cross-Sectional Studies, Family, Cognition Disorders, Sex Factors, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Netherlands, Female, Male, Adiponectin, Young Adult, Executive Function