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The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be analyzed with genome-wide profiling. In a discovery sample, a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested in two population-based samples of elderly participants. The genetic risk profiles were evaluated for depression and anxiety in the Rotterdam Study cohort and the Erasmus Rucphen Family (ERF) study. The genetic risk scores were significantly associated with different measures of depression and explained up to ∼0.7% of the variance in depression in Rotterdam Study and up to ∼1% in ERF study. The genetic score for depression was also significantly associated with anxiety explaining up to 2.1% in Rotterdam study. These findings suggest the presence of many genetic loci of small effect that influence both depression and anxiety. Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples.

Original publication

DOI

10.1038/mp.2010.65

Type

Journal article

Journal

Molecular psychiatry

Publication Date

07/2011

Volume

16

Pages

773 - 783

Addresses

Genetic Epidemiology Unit of the Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Keywords

Humans, Genetic Predisposition to Disease, Risk Factors, Cohort Studies, Depression, Anxiety, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study