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PURPOSE: Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and a target for inhibition therapy in wet age-related macular degeneration (AMD). The purpose of this study was to examine whether genetic variation in the VEGF gene is associated with AMD and, especially, with its wet end stage. DESIGN: Prospective population-based cohort study. PARTICIPANTS: Four thousand two hundred twenty-eight participants aged 55 years and older. METHODS: AMD was classified according to a modified International Classification System using fundus color images. Genotypes and haplotypes were determined for 3 functional VEGF single nucleotide polymorphisms (SNPs): C-2578A, G-1154A, and G-634C. Cox proportional hazards regression analyses were used to investigate possible associations between the individual SNPs and incident AMD. The Haplo.Stats program was used to test the associations between VEGF gene haplotypes and incident AMD. MAIN OUTCOME MEASURE: AMD RESULTS: Of 4228 participants at risk for incident early and late AMD for whom blood specimens were available for VEGF genotyping, incident early AMD developed in 514 and incident late AMD developed in 89 (35 dry and 54 wet) after a mean follow-up of 7.4 years. None of the SNPs showed a significant association with incident early or late AMD, especially not with incident wet AMD. Haplotype analyses also detected no associations. CONCLUSIONS: The a priori hypothesis that 3 common SNPs in the VEGF gene would be a risk factor for AMD, especially the wet form, could not be confirmed.

Original publication

DOI

10.1016/j.ophtha.2008.06.026

Type

Journal article

Journal

Ophthalmology

Publication Date

11/2008

Volume

115

Pages

1899 - 1903

Addresses

Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.

Keywords

Humans, Macular Degeneration, Vascular Endothelial Growth Factor A, Incidence, Proportional Hazards Models, Risk Factors, Follow-Up Studies, Prospective Studies, Polymerase Chain Reaction, Genotype, Haplotypes, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Netherlands, Female, Male