Estimates of functional connectivity using resting state functional Magnetic Resonance Imaging (rs-fMRI) are acutely sensitive to artifacts and large scale nuisance variation. As a result much effort is dedicated to preprocessing rs-fMRI data and using diagnostic measures to identify bad scans. One such diagnostic measure is DVARS, the spatial root mean square of the data after temporal differencing. A limitation of DVARS however is the lack of concrete interpretation of the absolute values of DVARS, and finding a threshold to distinguish bad scans from good. In this work we describe a sum of squares decomposition of the entire 4D dataset that shows DVARS to be just one of three sources of variation we refer to as D-var (closely linked to DVARS), S-var and E-var. D-var and S-var partition the sum of squares at adjacent time points, while E-var accounts for edge effects; each can be used to make spatial and temporal summary diagnostic measures. Extending the partitioning to global (and non-global) signal leads to a rs-fMRI DSE table, which decomposes the total and global variability into fast (D-var), slow (S-var) and edge (E-var) components. We find expected values for each component under nominal models, showing how D-var (and thus DVARS) scales with overall variability and is diminished by temporal autocorrelation. Finally we propose a null sampling distribution for DVARS-squared and robust methods to estimate this null model, allowing computation of DVARS p-values. We propose that these diagnostic time series, images, p-values and DSE table will provide a succinct summary of the quality of a rs-fMRI dataset that will support comparisons of datasets over preprocessing steps and between subjects.
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Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK; Institute for Advanced Studies, University of Warwick, Coventry, CV4 7AL, UK; Institute for Digital Healthcare, WMG, University of Warwick, Coventry, CV4 7AL, UK. Electronic address: firstname.lastname@example.org.
Brain, Nerve Net, Humans, Magnetic Resonance Imaging, Artifacts, Brain Mapping, Image Processing, Computer-Assisted, Datasets as Topic