African trypanosomes evade humoral immunity through antigenic variation, whereby they switch expression of the gene encoding their VSG (variant surface glycoprotein) coat. Switching proceeds by duplication of silent VSG genes into a transcriptionally active locus. The genome project has revealed that most of the silent archive consists of hundreds of subtelomeric VSG tandem arrays, and that most of these are not functional genes. Precedent suggests that they can contribute combinatorially to the formation of expressed, functional genes through segmental gene conversion. These findings from the genome project have major implications for evolution of the VSG archive and for transmission of the parasite in the field.

Original publication

DOI

10.1042/bst20050986

Type

Journal article

Journal

Biochemical Society transactions

Publication Date

11/2005

Volume

33

Pages

986 - 989

Addresses

University of Glasgow, Glasgow G12 8QQ, Scotland, UK. j.d.barry@bio.gla.ac.uk

Keywords

Animals, Trypanosomatina, Variant Surface Glycoproteins, Trypanosoma, Antigens, Protozoan, Evolution, Molecular, Genome, Genetic Variation