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BACKGROUND:So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. METHODS:We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ∼60 000 individuals in the discovery stage and ∼90 000 samples in the replication stage. RESULTS:Our study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. CONCLUSIONS:This study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.

Original publication

DOI

10.1136/jmedgenet-2015-103439

Type

Journal article

Journal

Journal of medical genetics

Publication Date

07/2016

Volume

53

Pages

441 - 449

Addresses

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Keywords

LifeLines Cohort Study, CHARGE Lipids Working Group, Humans, Angiopoietins, Fasting, Genotype, Polymorphism, Single Nucleotide, Genome, Human, Exons, Middle Aged, Female, Male, Genome-Wide Association Study, Angiopoietin-like 4 Protein