Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to activity in a seed region of interest (seed ROI) in a given psychological context, such as during attention or in the presence of emotive stimuli. In this tutorial, we aim to give a simple conceptual explanation of how PPI analysis works, in order to assist readers in planning and interpreting their own PPI experiments.

Original publication

DOI

10.1093/scan/nss055

Type

Journal article

Journal

Social cognitive and affective neuroscience

Publication Date

06/2012

Volume

7

Pages

604 - 609

Addresses

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. joreilly@fmrib.ox.ac.uk

Keywords

Brain, Neural Pathways, Humans, Oxygen, Magnetic Resonance Imaging, Psychophysiology, Brain Mapping, Task Performance and Analysis, Image Processing, Computer-Assisted