Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

Original publication

DOI

10.1038/ng.1051

Type

Journal article

Journal

Nature genetics

Publication Date

22/01/2012

Volume

44

Pages

260 - 268

Addresses

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Keywords

LifeLines Cohort Study, Humans, DNA Repair Enzymes, Exodeoxyribonucleases, DNA Helicases, DNA-Directed DNA Polymerase, DNA Primase, Proteins, Age Factors, Immunity, DNA Repair, Menopause, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Female, Genome-Wide Association Study, Genetic Loci, DNA Polymerase gamma