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Resistance of Streptococcus pneumoniae to antimicrobial drugs is increasing. To investigate the relationship between antimicrobial use and susceptibility of S. pneumoniae isolates at 24 U.S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-lactam antimicrobial drugs.

Original publication

DOI

10.3201/eid0605.000519

Type

Journal article

Journal

Emerging infectious diseases

Publication Date

09/2000

Volume

6

Pages

552 - 556

Addresses

University of Iowa College of Medicine, Iowa City, Iowa 52242, USA. daniel-diekema@uiowa.edu

Keywords

Humans, Streptococcus pneumoniae, Erythromycin, Microbial Sensitivity Tests, Analysis of Variance, Penicillin Resistance, United States