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Lupus nephritis (LN), a common manifestation of systemic lupus erythematosus (SLE), accounts for significant morbidity and mortality in SLE patients. Since the available standard therapies and biologic agents for LN are yet to achieve the desired response and have considerable secondary effects, stem cell therapy has now emerged as a new approach. This therapy involves the transplantation of hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Our current review will highlight the progress of stem cell therapy for LN, along with the challenges encountered and the future direction of this approach.

Original publication

DOI

10.1177/0961203318793206

Type

Journal article

Journal

Lupus

Publication Date

10/2018

Volume

27

Pages

1881 - 1897

Addresses

1 Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr Sardjito General Hospital, Indonesia.

Keywords

Stem Cells, Humans, Lupus Nephritis, Mesenchymal Stem Cell Transplantation