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Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10-06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = -0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10-08), nine of which replicate (P -25) on migraine than SBP (1.05 [1.03-1.07]/10 mmHg; P = 2.60 × 10-07) and a corresponding opposite effect for PP (0.92 [0.88-0.95]/10 mmHg; P = 3.65 × 10-07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.

Original publication

DOI

10.1038/s41467-020-17002-0

Type

Journal article

Journal

Nature communications

Publication Date

07/2020

Volume

11

Addresses

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA. yguo19@bwh.harvard.edu.

Keywords

International Headache Genetics Consortium, 23andMe Research Team, Humans, Hypertension, Genetic Predisposition to Disease, Telomerase, Proteins, Receptors, Adrenergic, alpha-2, Integrin beta Chains, Risk Factors, Blood Pressure, Polymorphism, Single Nucleotide, Migraine Disorders, Meta-Analysis as Topic, Genome-Wide Association Study, Mendelian Randomization Analysis