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Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide.

van Driel LMJW., Smedts HPM., Helbing WA., Isaacs A., Lindemans J., Uitterlinden AG., van Duijn CM., de Vries JHM., Steegers EAP., Steegers-Theunissen RPM.

AimsCongenital heart defects (CHDs) have a multifactorial origin, in which subtle genetic factors and peri-conception exposures interact. We hypothesize that derangements in the homocysteine and detoxification pathways, due to a polymorphism in the nicotinamide N-methyltransferase (NNMT) gene, low maternal dietary nicotinamide intake, and medicine use in the peri-conception period, affect CHD risk.Methods and resultsIn 292 case and 316 control families, maternal peri-conception medicine use and low dietary intake of nicotinamide (ConclusionChildren carrying the NNMT A allele face additional CHD risk in combination with peri-conception exposure to medicines and/or a low dietary nicotinamide intake. These findings provide a first set of data against which future studies with larger sample sizes can be compared with.

More information Original publication

DOI

10.1093/eurheartj/ehn170

Type

Journal article

Publication Date

2008-06-01T00:00:00+00:00

Volume

29

Pages

1424 - 1431

Total pages

7

Addresses

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Keywords

Humans, Prenatal Exposure Delayed Effects, Heart Defects, Congenital, Hyperhomocysteinemia, Genetic Predisposition to Disease, Niacinamide, Vitamin B Complex, Epidemiologic Methods, Pregnancy, Genotype, Polymorphism, Single Nucleotide, Adult, Child, Female, Male, Nicotinamide N-Methyltransferase, Drug-Related Side Effects and Adverse Reactions