Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors.
Schelleman H., Klungel OH., van Duijn CM., Witteman JCM., Hofman A., de Boer A., Stricker BHC.
AimsWe investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.MethodsThis was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).ResultsDuring follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.ConclusionsThe I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.