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Recent outbreaks, including the coronavirus disease 2019 (COVID-19) pandemic, have highlighted the importance of mathematical and statistical modelling in understanding the drivers of transmission and how to tailor responses. Improving future responses requires lessons from these previous outbreaks to be learned and the remaining challenges overcome. This requires developing appropriate mathematical, statistical and computational frameworks that accurately capture the studied mechanisms, leading to a better understanding of how different data can affect these formulations or the simulated interventions. Furthermore, improving model validation and quantifying uncertainty in the model parameter estimates and projections when applied responsively across settings and diseases is also required. Via a collection of 22 papers, this special issue brings together both theoretical advances and applied modelling innovations aimed at improving epidemic and pandemic preparedness and response. It includes articles that develop novel statistical inference approaches, as well as sophisticated and data-informed mathematical models, enhanced simulation techniques, exploration of heterogeneities in disease transmission both across ages and settings and the use of modelling techniques to evaluate intervention strategies across different diseases and settings to improve public health outcomes.

More information Original publication

DOI

10.1016/j.jtbi.2026.112424

Type

Journal article

Publication Date

2026-05-01T00:00:00+00:00

Volume

625

Addresses

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Keywords

Humans, Communicable Diseases, Disease Outbreaks, Pandemics, COVID-19, SARS-CoV-2