Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Ridnour LA., Heinz WF., Cheng RYS., Wink AL., Kedei N., Pore M., Imtiaz F., Femino EL., Gonzalez AL., Coutinho LL., Moffat RL., Butcher D., Edmondson EF., Li X., Rangel MC., Kinders RJ., Rittscher J., Lipkowitz S., Wong STC., Anderson SK., McVicar DW., Glynn SA., Billiar TR., Chang JC., Hewitt SM., Ambs S., Lockett SJ., Wink DA.

SignificanceThis work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.

DOI

10.1158/2767-9764.crc-24-0235

Type

Journal article

Publication Date

2024-10-01T00:00:00+00:00

Volume

4

Pages

2766 - 2782

Total pages

16

Addresses

Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.

Keywords

CD8-Positive T-Lymphocytes, Animals, Humans, Mice, Breast Neoplasms, Neoplasm Metastasis, Receptors, Estrogen, Female, Cyclooxygenase 2, Nitric Oxide Synthase Type II, Neoplastic Stem Cells, Stem Cell Niche, Tumor Microenvironment

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