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The management of patients with cancer involves the administration of complex treatment protocols with frequent monitoring of the effects of treatment on the malignant disease as well as on the general health of the patient. The number and wide variety of protocols used in treatment trials, and the amount of clinical data generated suggest the need for computer-based support. The toxicity of many of the treatments used and the severity of the disease itself underline the safety-critical nature of all decisions made by oncologists, the physicians and surgeons who treat cancer patients. This paper presents recent work on the analysis of safety issues arising from the design and implementation of a prototype decision-support system for oncologists. It illustrates the benefits of combining both informal and formal approaches to the analysis and representation of safety, firmly based on a thorough and detailed study of the domain in cooperation with oncologists, pharmacists and medical informaticians.

Type

Journal article

Journal

Methods of information in medicine

Publication Date

10/1994

Volume

33

Pages

371 - 381

Addresses

Advanced Computation Laboratory, Imperial Cancer Research Fund, London, UK.

Keywords

Humans, Neoplasms, Antineoplastic Agents, Clinical Protocols, Drug Therapy, Computer-Assisted, Drug Administration Schedule, Medical Oncology, Safety Management, Decision Support Techniques, Expert Systems