Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patients were included at a similar stage, i.e., before the onset of symptoms, and followed for up to 5 years. We found that the APOE*4 allele is not a strong determinant of survival in AD. As change in cognitive function and severity of dementia are similar for AD patients with and without APOE*4, our study suggests that progression of AD is not related to the APOE*4 allele.

Original publication

DOI

10.1007/s004150050351

Type

Journal article

Journal

Journal of neurology

Publication Date

04/1999

Volume

246

Pages

304 - 308

Addresses

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands. slooter@epib.fgg.eur.nl

Keywords

Humans, Dementia, Alzheimer Disease, Disease Progression, Apolipoproteins E, Prognosis, Survival Analysis, Cohort Studies, Follow-Up Studies, Cognition, Alleles, Aged, Middle Aged, Female, Male