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BACKGROUND AND DESIGN: The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study. METHODS: Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk. RESULTS: High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02). CONCLUSION: This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.

Original publication

DOI

10.1097/hjr.0b013e32801101aa

Type

Journal article

Journal

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology

Publication Date

06/2007

Volume

14

Pages

419 - 421

Addresses

Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.

Keywords

Humans, Myocardial Infarction, Genetic Predisposition to Disease, Lipoproteins, HDL, Population Surveillance, Incidence, Linear Models, Proportional Hazards Models, Risk Assessment, Risk Factors, Follow-Up Studies, Prospective Studies, Sex Factors, Up-Regulation, Gene Frequency, Polymorphism, Genetic, Time Factors, Middle Aged, Netherlands, Female, Male, Atherosclerosis, Cholesterol Ester Transfer Proteins