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Background and designThe effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study.MethodsQuantitative outcomes were studied with linear models; Cox models were used to assess MI risk.ResultsHigh-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02).ConclusionThis study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.

Original publication




Journal article


European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology

Publication Date





419 - 421


Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.


Humans, Myocardial Infarction, Genetic Predisposition to Disease, Lipoproteins, HDL, Population Surveillance, Incidence, Linear Models, Proportional Hazards Models, Risk Assessment, Risk Factors, Follow-Up Studies, Prospective Studies, Sex Factors, Up-Regulation, Gene Frequency, Polymorphism, Genetic, Time Factors, Middle Aged, Netherlands, Female, Male, Atherosclerosis, Cholesterol Ester Transfer Proteins