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The APOE*4 allele of the apolipoprotein E gene (APOE) is an important risk factor for Alzheimer's disease. It has been suggested that levels of apolipoprotein E (apoE) in plasma are increased in Alzheimer's disease. In this population-based study, we found that serum apoE levels were lower in Alzheimer patients compared to non-demented controls (0.75 micromol/l (SD 0.35), vs. 0.83 micromol/l (SD 0.40), P < 0.05). This finding is in accordance with lower serum apoE levels as observed in carriers of the APOE*4 allele, who are over-represented in Alzheimer's disease. After adjustment for age, sex, total protein, albumin level, body mass index and the APOE genotype, the difference in serum apoE levels largely disappeared. Our population-based study suggests that the differences in serum apoE level between Alzheimer patients and controls are mainly the result of differences in the distribution of the APOE genotype.

Original publication

DOI

10.1016/s0304-3940(98)00339-5

Type

Journal article

Journal

Neuroscience letters

Publication Date

05/1998

Volume

248

Pages

21 - 24

Addresses

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands. slooter@epib.fgg.eur.nl

Keywords

Humans, Alzheimer Disease, Apolipoproteins E, Cohort Studies, Genotype, Aged, Aged, 80 and over, Middle Aged, Female, Male