Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but 13 are novel. Collectively, single-nucleotide polymorphisms associated with hair color within these loci explain 34.6% of red hair, 24.8% of blond hair, and 26.1% of black hair heritability in the study populations. These results confirm the polygenic nature of complex phenotypes and improve our understanding of melanin pigment metabolism in humans.

Original publication

DOI

10.1038/s41588-018-0100-5

Type

Journal article

Journal

Nature genetics

Publication Date

05/2018

Volume

50

Pages

652 - 656

Addresses

King's College London Department of Twins Research and Genetic Epidemiology, London, UK.

Keywords

International Visible Trait Genetics Consortium, Chromosomes, Human, X, Humans, Hair Color, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide, Aged, Middle Aged, European Continental Ancestry Group, Female, Male, Genome-Wide Association Study, Genetic Loci