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We have investigated the genetic involvement of the CD4 and the LAG3 genes, two appealing candidates for MS due to their suggested role in MS pathology. We genotyped a Swedish case-control material consisting of 920 MS patients and 778 controls in an initial study of CD4, three SNPs showed a significant association with MS. An independent material consisting of 1720 Nordic MS patients and 1416 controls were used for confirmation of associated markers in CD4 and to do a confirmative study of the LAG3 gene from previous findings. The result, including a total of 2640 MS patients and 2194 controls shows no significant association with CD4 and LAG3 and MS. We conclude that these genes are of minor importance in regard of genetic predisposition to the MS.

Original publication

DOI

10.1016/j.jneuroim.2006.08.009

Type

Journal article

Journal

Journal of neuroimmunology

Publication Date

11/2006

Volume

180

Pages

193 - 198

Addresses

Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden. frida.lundmark@ki.se

Keywords

Humans, Multiple Sclerosis, Genetic Predisposition to Disease, Antigens, CD, Genetic Markers, Case-Control Studies, Cohort Studies, Predictive Value of Tests, DNA Mutational Analysis, Gene Frequency, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Adult, Middle Aged, European Continental Ancestry Group, Finland, Denmark, Norway, Sweden, Female, Male, Genetic Testing, Biomarkers, CD4 Antigens