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The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.

Original publication

DOI

10.1126/science.287.5454.845

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

02/2000

Volume

287

Pages

845 - 848

Addresses

Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, UK. marian.bruce@ceid.ox.ac.uk

Keywords

Animals, Humans, Plasmodium, Plasmodium falciparum, Plasmodium malariae, Plasmodium vivax, Parasitemia, Malaria, Malaria Vaccines, Species Specificity, Genotype, Adolescent, Child, Child, Preschool, Papua New Guinea, Female, Male