We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Original publication

DOI

10.1038/ng.639

Type

Journal article

Journal

Nature genetics

Publication Date

09/2010

Volume

42

Pages

739 - 741

Addresses

Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Keywords

African TB Genetics Consortium, Wellcome Trust Case Control Consortium, Chromosomes, Human, Pair 18, Humans, Tuberculosis, Genetic Predisposition to Disease, Odds Ratio, Case-Control Studies, Genetics, Population, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Gambia, Ghana, Genome-Wide Association Study, Genetic Loci