Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.

Original publication

DOI

10.1186/s13073-017-0474-5

Type

Journal article

Journal

Genome medicine

Publication Date

18/09/2017

Volume

9

Addresses

National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK. michael.holmes@ndph.ox.ac.uk.

Keywords

Humans, Cardiovascular Diseases, Insulin Resistance, Adiposity, Epigenomics