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Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Original publication

DOI

10.1038/ncomms11008

Type

Journal article

Journal

Nature communications

Publication Date

29/03/2016

Volume

7

Addresses

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.

Keywords

Consortium for Refractive Error and Myopia, Humans, Refractive Errors, Genetic Predisposition to Disease, Gene Expression Profiling, Environment, Polymorphism, Single Nucleotide, Asian Continental Ancestry Group, European Continental Ancestry Group, Educational Status, Genome-Wide Association Study, Genetic Loci