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Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.

Original publication

DOI

10.1179/2046905515y.0000000009

Type

Journal article

Journal

Paediatrics and international child health

Publication Date

05/2016

Volume

36

Pages

118 - 121

Addresses

b Department of Infectious Diseases , Addenbrookes Hospital , Cambridge , UK.

Keywords

Humans, Salmonella typhi, Typhoid Fever, Bacteriological Techniques, Sensitivity and Specificity, Retrospective Studies, Child, Child, Preschool, Cambodia, Female, Male, Blood Culture