Androgens are key regulators of prostate gland maintenance and prostate cancer growth, and androgen deprivation therapy has been the mainstay of treatment for advanced prostate cancer for many years. A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes.We investigated the association of AR sequence variants with circulating sex hormone levels and prostate cancer risk in 6058 prostate cancer cases and 6725 controls of Caucasian origin within the Breast and Prostate Cancer Cohort Consortium. We genotyped a highly polymorphic CAG microsatellite in exon 1 and six haplotype tagging single nucleotide polymorphisms and tested each genetic variant for association with prostate cancer risk and with sex steroid levels.We observed no association between AR genetic variants and prostate cancer risk. However, there was a strong association between longer CAG repeats and higher levels of testosterone (P = 4.73 x 10(-5)) and estradiol (P = 0.0002), although the amount of variance explained was small (0.4 and 0.7%, respectively).This study is the largest to date investigating AR sequence variants, sex steroid levels, and prostate cancer risk. Although we observed no association between AR sequence variants and prostate cancer risk, our results support earlier findings of a relation between the number of CAG repeats and circulating levels of testosterone and estradiol.

Original publication

DOI

10.1210/jc.2009-1911

Type

Journal article

Journal

The Journal of clinical endocrinology and metabolism

Publication Date

09/2010

Volume

95

Pages

E121 - E127

Addresses

Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

Keywords

Humans, Carcinoma, Breast Neoplasms, Prostatic Neoplasms, Genetic Predisposition to Disease, Gonadal Steroid Hormones, Receptors, Androgen, Risk, Case-Control Studies, Cohort Studies, Trinucleotide Repeats, Germ-Line Mutation, Aged, Middle Aged, United States, Female, Male, National Cancer Institute (U.S.), Genetic Association Studies