Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

Original publication

DOI

10.1093/infdis/jiu608

Type

Journal article

Journal

The Journal of infectious diseases

Publication Date

04/2015

Volume

211

Pages

1352 - 1355

Addresses

KEMRI/United States Army Medical Research Unit-Kenya, Kisumu.

Keywords

Humans, Plasmodium falciparum, Malaria, Falciparum, Artemisinins, Antimalarials, Drug Resistance, Gene Frequency, Mutation, Polymorphism, Single Nucleotide, Alleles, Asia, Southeastern